0. The claim that philosophy is dead seems overblown and arrogant. The questions listed as belonging to philosophy in the past are not questions philosophy has dealt with for some time.
1. The book covers an enormous range of topics in physics—none in depth. All depend on rather sophisticated mathematics which must be omitted. The entire effort is directed at presenting an intuitive picture of the science involved while at the same time making the case for models which are not at all intuitive.
2. Naturally in a small book covering a vast field in less than 200 pages with many illustrations, much gets left out and much is oversimplified, but this book seemed less informative than many NOVA programs. It's a bit too simple and too brief to a really good job, a sort of hodgepodge of theories.
3. Model-dependent realism is a metaphysical and epistemological concept that needs more serious discussion than it gets in this book. The connection with other philosophical notions such as phenomenology are interesting, but the book never gets beyond simply saying that we have to give up ordinary ways of thinking. An idea this deep needs much more preparation.
4. Feynman's many histories interpretation of quantum mechanics is treated as established science rather than an interpretation or a method and there is no mention of other views of quantum mechanics. There is much speculation on the so-called multiverse that gives the book a "gee-whiz" flavor.
The book has had spectacular reviews—anything Hawking writes gets spectacular reviews—that don't seem fully deserved. A better and more serious book would probably not sell as well and this book looks designed to sell.